Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.
The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.
2021 Eaton Foundation Fellow:
Registration fees for this workshop have been generously sponsored by the Richard Eaton Foundation, the CRAVAT Foundation, and the University of Illinois at Chicago Department of Anesthesiology. This sponsorship covers workshop expenses as well as the cost of five breakfasts, a Wednesday-night BBQ picnic, and all the snacks you can eat. All participants are responsible for their own lodging and travel expenses.
We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.
TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Ah Haa School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on TSRC's website at https://www.telluridescience.org/travel/families. Please contact Cindy Fusting at firstname.lastname@example.org for more information.
|Hansen, Carsten Gram||Edinburgh University|
|Harvey, Kieran||Peter MacCallum Cancer Centre|
|Kouskoff, Valerie||University of Manchester|
|Ma, Li||The University of Texas MD Anderson Cancer Center|
|Misra, Jyoti||University of Texas at Dallas|
|Neil, Emily||University of Manchester|
|Szulzewsky, Frank||Fred Hutchinson Cancer Research Center|
|Tanas, Munir||University of Iowa|
|van Eeden, Freek||Bateson Centre/School of Bioscience|