This workshop will bring together global leaders in main-group chemistry to discuss the importance of studying and understanding atomic-to-molecular-to-materials level chemistry of main-group elements and systems. The primary goals of this workshop are to invoke an in-depth discussion on synthetic methods to prepare and manipulate main-group compounds and/or atoms, challenges in the characterization of these diverse, and often reactive, materials with atomic precision, and further inspire creative solutions to existing challenges in their use in key scientific areas. Focus will be given to applications in catalysis, biological and medically translational applications, materials chemistry as applied to battery and microelectronics technologies, and the fundamentals of structure, bonding and reactivity. This workshop is expected to foster collaborations between leaders in the field and inspire paradigm-altering approaches to the design, synthesis and utilization of main-group compounds for societally relevant, cutting-edge technologies.