Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.
The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.
2018 Eaton Foundation Fellows: Zachary Crook and Zhipeng Meng
Registration fees for this workshop have been generously sponsored by the Richard Eaton Foundation, the CRAVAT Foundation, and the University of Illinois at Chicago Department of Anesthesiology. This sponsorship covers workshop expenses as well as the cost of five breakfasts, a Wednesday-night BBQ picnic, and all the snacks you can eat. All participants are responsible for their own lodging and travel expenses.
If you are interested in attending this meeting, but have not received an invitation, please contact the lead workshop organizer, Guy Weinberg, about availability before registering. Most TSRC meetings are very small, typically only about 25 people. If you have registered for a meeting you were not invited to, you may be subject to a $100 fee.
Telluride Intermediate School
725 West Colorado Ave Telluride, CO 81435
|Costi, Maria Paola||University of Modena and Reggio Emilia|
|COTELLE, Philippe||Lille University|
|Crook, Zachary||Fred Hutch|
|Deel, Michael||Duke University|
|Hong, Wanjin||Institute of Molecular and Cell Biology|
|Johnson, Randy L.||University of Texas, MD Anderson Cancer Center|
|Kapus , Andras||Keenan Researh Centre|
|Kim, Nam Gyun||Seattle Children's Research Institute|
|Kim, Nam Gyun [2nd Reservation]||Seattle Children's Research Institute|
|Kofler, Michael||St Michael's Hospital Toronto|
|Lamar, John Michael||Albany Medical College|
|Meng, Zhipeng||University of California San Diego|
|Pendergast, Ann Marie||Duke University|
|Rubin, Brian P.||Cleveland Clinic|
|SUDOL, Marius||National University of Singapore|
|Varelas, Bob||Boston University|
|Wenzel, Pamela||University of Texas Health Science Center at Houst|