The development and application of culture-independent approaches (i.e. high throughput sequencing of bacterial and viral community DNA) has generated a profound shift in our understanding of chronic respiratory infections in cystic fibrosis (CF) patients. We now recognize the importance of polymicrobial interactions, environmental conditions and evolutionary adaptations in the progression of CF disease. Yet, a lack of ecological perspective has limited the translation of bench research into effective therapeutic strategies. For example, how do you describe the response of a bacterial community to an environmental condition, without direct measurements of these conditions in vivo? Recently, applications of integrated omics approaches (genomics, transcriptomics, proteomics, and metabolomic profiling) have shed light on the ecological dynamics of CF bacterial communities, though many outstanding questions remain. This will be the 6th bi-annual meeting of the TSRC CF workshop, which began in 2009 with the goal of building theoretical models of CF lung physiology to identify ecological and evolutionary instabilities. We will explore ecological and evolutionary approaches to modeling the CF lung environment and the microbiota that resides there, with the ultimate goal of devising more effective clinical therapies. In addition to a review of the last few TSRC CF meetings, talks from both basic scientists and clinicians will emphasize new tools and hypotheses about the CF bacterial ecosystem and its relation to disease progression. One-hour talks have been known to last an entire afternoon due to intensive probing from the audience. Come prepared to give chalk talks and/or show slides and plots about your work, anything that you feel is important!
A) Models of CF lung that help us identify evolutionary and ecological instabilities
B) Identify missing datasets that are critical for managing CF as an ecosystem
C) Exchange information amongst biologists, clinicians, and mathematicians
IMPORTANT: Participants should note that the workshop runs Saturday through Wednesday. Because of the Bluegrass Festival that starts on Thursday (17th), discounted lodging rates are not available on Wednesday night. If your flight is on Thursday out of Montrose, we recommend having dinner in Telluride on Wednesday night and taking Telluride Express to Montrose after dinner. TSRC scientists are eligible for the corporate rate ($119 + tax) at the Hampton Inn (970-547-4120) next to the airport. The Holiday Inn Express is also a good option too although we do not have a discount with them.
We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.
TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on TSRC's website. Feel free to contact TSRC's staff to help with any planning and/or coordinating care.
Telluride Intermediate School
725 West Colorado Ave Telluride CO 81435
|Conrad, Douglas||UC San Diego|
|Wagner, Brandie||University of Colorado|
|Whiteson, Katrine||University of California Irvine|