Workshop Details
YAP/TAZ and TEAD: At the Crossroads of Cancer (VIRTUAL PARTICIPANT)
06/07/2021 - 06/11/2021
Meeting Description:

Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.

The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.

2021 Eaton Foundation Fellow: Ryan Kanai
2021 CRAVAT Fellow: Caleb Seavey
2021 EHEFoundation Fellow: Keith Garcia


We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.

TSRC is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think.

With a workshop organizer's approval, students/post docs/lab members/retired senior scientists can register for $50 if they are not participating as a presenter. Please register at the normal rate and send an email to Sara Friedberg ( to let her know that you would like to participate at that rate. When you email her, please include the name of the workshop and the name of the workshop organizer who approved that participation rate. Thank you!

Meeting Venue:


YAP/TAZ and TEAD: At the Crossroads of Cancer (VIRTUAL PARTICIPANT) Registered Meeting Participants:
Participant Organization
Driskill, Jordan UTSW
Guan, Kun-Liang University of California, San Diego
Harvey, Kieran Peter MacCallum Cancer Centre
Holden, Jeff Genentech
Hong, Wanjin Institute of Molecular and Cell Biology
Kapus, Andras St. Michaels Hospital, LKSKI
Neil, Emily University of Manchester
Pendergast, Ann Marie Duke University
Rubin, Brian P. Cleveland Clinic
Szulzewsky, Frank Fred Hutchinson Cancer Research Center
van Eeden, Freek Bateson Centre/BMS
Varelas, Bob Boston University
Zhang, Jianmin Roswell Park Cancer Institute

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