Workshop Details
YAP/TAZ and TEAD: At the Crossroads of Cancer
06/25/2023 - 06/29/2023
Meeting Description:

Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.

The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.

2023 Eaton Foundation Fellow: Xinwei Cao


IMPORTANT: Participants should be aware that this workshop runs Sunday through Thursday. The 4th of July lodging rates will go into effect on the night of Thursday the 29th. To avoid the rate increase, you should depart on the evening of the 29th. If your flight out of Montrose does not leave until Friday the 30th, we suggest eating dinner in Telluride on the night of the 29th, taking the shuttle to Montrose after dinner, and staying at the Hampton Inn (970-547-4120) next to the airport. You will receive a discount at the Hampton Inn by saying you are a TSRC scientist.

We wish to ensure an intimate workshop setting, with no more than 20 to 25 participants. If you are interested in attending, but have not received an invitation, please contact the workshop organizer before registering.

Telluride Science is about expanding the frontiers of science, exploring new ideas, and building collaborations. The workshop schedule will allow for substantial unstructured time for participants to talk and think. All participants are expected to stay for the entire duration of the workshop. Scientists are encouraged to consider bringing family or friends. Telluride offers a number of options for children's camps (including Telluride Academy, Aha School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on Telluride Science's website. Feel free to contact Telluride Science's staff to help with any planning and/or coordinating care.

Meeting Venue:

Telluride Intermediate School
721 West Colorado Ave Telluride, CO 81435

YAP/TAZ and TEAD: At the Crossroads of Cancer Registered Meeting Participants:
Participant Organization
Cao, Xinwei St. Jude Children's Research Hospital
DeWane, Gillian University of Iowa
Guan, Kun-Liang University of California, San Diego
Halder, Georg University of Leuven
Harvey, Kieran Peter MacCallum Cancer Centre
Kapus, Andras Keenan Researh Centre
Lamar, John Albany Medical College
Meng, Zhipeng University of Miami
Pendergast, Ann Marie Duke University
Rubin, Brian P. Cleveland Clinic
Scalora, Nicholas University of Iowa
Tanas, Munir University of Iowa
Tang, Tracy Vivace Therapeutics
Tapon, Nic Francis Crick Institute
Varelas, Bob Boston University
Weinberg, Guy University of Illinois
Yechoor, Vijay University of Pittsburgh
Yuen, Darren Unity Health Toronto
Zhang, Jianmin Roswell Park Cancer Institute

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