The purpose of the workshop is to bring together leading experts, theorists and experimentalists, in the spectroscopy and dynamics of systems with anharmonic, coupled large-amplitude vibrations. We expect the systems covered by the workshop to include small floppy molecules, hydrogen-bonded and other weakly bound complexes, molecules adsorbed on surfaces or in the interior of nanoporous materials, biomolecules and peptides, both in the gas phase and hydrated, and water itself. Experimental manifestations of the vibrations in these systems contain a wealth of information about the dynamics, geometries/conformations, potential energy surfaces, and other properties. However, extracting this information is possible only with the help of sophisticated theoretical computations. The latter are very challenging, because of the dimensionality of the problem and the often complex potential energy landscape. Developing theoretical methods capable of tackling such systems is a very active area of research.