Workshop Details
YAP/TAZ and TEAD: At the Crossroads of Cancer
06/25/2024 - 06/29/2024
Meeting Description:

Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.

The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.

2023 Eaton Foundation Fellow: Xinwei Cao

Notes:

IMPORTANT: Participants should be aware that this workshop runs Tuesday through Saturday. Discounted lodging rates begin on Monday, June 24th. If you are planning to arrive on Sunday, you can stay at the Hampton Inn (970-547-4120) next to the airport and come up to Telluride first thing on Monday. You will receive a discount at the Hampton Inn by saying you are a TSRC scientist.

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most Telluride Science meetings are very small, typically only about 25 people. Please contact the organizers if you would like an invitation.

Telluride offers a number of options for children's camps (including Telluride Academy, Ah Haa School for the Arts, and Pinhead Institute). There is more information on childcare, camps, and family activities on Telluride Science's website at https://www.telluridescience.org/travel/families. Please contact Cindy Fusting at cindy@telluridescience.org for more information.

Meeting Venue:

The Telluride Intermediate School
721 W Colorado Ave Telluride, CO 81435
Click Here for Directions

Meeting Details:

Workshop Price: $ 0.00
Early Bird Lodging Discount Available Until: 01/31/2024

A $100.00 discount is applied to your lodging cost when you register before 01/31/2024.

Cancellation Policy: Once a credit card has been charged, cancelled registrations will be subject to a cancellation fee. Registration fees will be automatically processed once registration is complete. A $25 cancellation fee will be retained from a registration refund. Lodging fee payments will be processed 60 days prior to arrival, and a $100 cancellation fee will apply if cancellations occur after a lodging fee payment is completed. Telluride Science can only guarantee a refund for the remaining lodging fees if requested prior to the cancellation deadline that is specific to each lodging provider. Telluride Science recommends that participants purchase travel insurance to protect against unforeseen, last-minute travel plan changes.

YAP/TAZ and TEAD: At the Crossroads of Cancer Registered Meeting Participants:
Participant Organization
Aplin, Andrew Thomas Jefferson University
Attisano, Liliana University of Toronto
DeWane, Gillian University of Iowa
DiPersio, Michael Albany Medical College
Lamar, John Albany Medical College
Li, Shuo Cleveland Clinic
McMullan, Sarah Albany Medical College
Moulik, Mousumi University of Pittsburgh
Muller, Florian PowderGate Discovery
Pasquali, Sandro Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
Pendergast, Ann Marie Duke University
Tang, Tracy Vivace Therapeutics
Varelas, Bob Boston University
Weinberg, Guy University of Illinois
Wrana, Jeff Lunenfeld-Tanenbaum Research Institute
Yang, Yingzi Harvard School of Dental Medicine
Yechoor, Vijay University of Pittsburgh
Yuen, Darren Unity Health Toronto
Zhang, Jianmin Roswell Park Cancer Institute

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