This Telluride Science workshop will bring in global leaders in the field of synthetic porous frameworks, namely metal-organic and covalent organic frameworks, to discuss the importance of studying and understanding atomic-to-molecular level chemistry in three-dimensionally connected porous framework materials. The primary goals of this workshop are to invoke an in-depth discussion on synthetic methods to express molecular properties in framework materials, challenges in characterization of these extended, and often dynamic, materials with atomic precision, and further inspire creative solutions to existing challenges in their use in critical applications, including atmospheric water collection, negative emissions, solar energy harvesting, and low energy catalysis. This workshop is expected to foster collaborations between the leaders in this field and inspire paradigm altering approaches to the design and synthesis of porous framework materials for societally beneficial technologies.