This workshop focuses on the complexity of dynamics and kinetics in complex systems, such as proteins, in terms of the underlying multidimensional energy landscape, the network structure in the conformational, or, in general, state space, and various mathematical models of nature. We aim at having an interdisciplinary meeting that brings both theoretical and experimental researchers together from different fields including time series analysis, energy landscape, statistical physics, network analysis, and single molecule experiments.
This year, the main questions to be addressed are:
1. What are the current and next generation experimental advances to probe the dynamics and kinetics of complex biophysical systems, such as single molecule spectroscopy and microscopy, cell imaging, multi-parameter measurements, and what are the desired analysis methods to scrutinize the observed data?
2. What are the appropriate mathematical languages to model complex dynamics and kinetics from experiments or computer simulations, such as generalized Langevin equations, master equations, networks, disconnectivity graphs? How can the mathematical models be constructed from scalar, multivariate or imaging (spatiotemporal) data? For example, how to extract hidden dimensions, how to reduce dimensions?
3. What are the dynamical and thermodynamical signatures of the constructed models? The related subjects are, for example, diffusion properties, memory effects, the quantification of multiple pathways on the energy landscape and its relations to the protein structures, equilibrium and nonequilibrium properties.
4. If the constructed models are complicated, e.g. in the conformational-space network, how can the essential features be extracted and represented, such as coarse-grained models, quantifying the large scale structure of networks, identifying reaction coordinates and flux?
This Telluride workshop is different from a traditional conference. This workshop is aimed at exploring the new, exciting, open questions, by stirring different disciplines working on different subjects and fields rather than solely to learn about all the wonderful things the participants have already done. Some of the most interesting Telluride
workshops have used a format in which the first day or the half of the first day is devoted to setting an agenda of the open topics to be discussed, choosing who should be the formal presenter of each of those topics, and setting the day for each presentation. The material that would, in a traditional conference be presented in a talk, would have
been contained in the pre-circulated papers. Then everyone will know the substance of where each subject stands and the focus can be on what needs to be investigated next, and how those things could be approached. We plan to follow this pattern, and will ask the participants to submit
one or two papers that they would like the others to see, and to send us a list of the exciting, important open problems that they feel should be discussed at this workshop.
Telluride Intermediate School
725 W Colorado Ave Telluride CO 81435
|Berry, R. Stephen||University of Chicago|
|Blank, Kerstin||RUNijmegen, IMM|
|Chu, Jhih-Wei||UC Berkeley|
|Hernandez, Rigoberto||Georgia Tech|
|Kamagata, Kiyoto||Tohoku University|
|Komatsuzaki, Tamiki||Hokkaido University|
|Li, Chun Biu||Research Institute for Electronic Science, Hokkaid|
|Nerukh, Dmitry||Aston University|
|Pearson, John||Los Alamos National Laboratory|
|Riccardi, Laura||Freiburg University|
|Terentyeva, Tatyana||KU Lueven, VAT BE419052173|
|Wang, Jin||Stony Brook University|
|Wu, Jianlan||Physics Deparment, Zhejiang University|
|Yang, Haw||Princeton University|