New approaches to cystic fibrosis (CF) have recently become available in both the experimental and the theoretical arenas. In the experimental arena, large scale metagenomics on sputum samples has revealed many more species present than traditional culturing methods. MRI scans of CF promise location specific growth data observable often and giving some of the same information that only CT scans could provide. These techniques have made the dynamics of the CF lung as an ecosystem accessible to observation. Such observation needs guidance from theory. The workshop will explore ecological and evolutionary approaches to modeling the CF lung and their application to devising an optimal treatment regimen. The 2009 TSRC workshop on this theme focused on building mathematical models. Much of that work that has been done, and will be summarized in the first couple of days of the meeting. But as with all good Telluride workshops, the aim is to do research on-site. One-hour talks last two hours due to intensive probing from the audience. Come prepared to give chalk talks and/or Powerpoint about your work...especially things that you think are important.