Motions of RNA molecules are intrinsic to their function as enzymes, as the active components of the ribosome, as riboswitches, as small RNAs that regulate gene expression, and as they bind to proteins and small molecules. Characterizing their motions is the next great challenge of in vitro experiment and computational methods, since not only does RNA have extensive global and local motions on many timescales, but as polyanions they are theoretically very challenging. This workshop is designed to bring together about 30 experimental and computational scientists who present their work in the context of what is known and what needs to be discovered. The format is discussion of theory and practice and how the two can be integrated. Attendees study RNA using NMR, single molecule, thermodynamics, molecular dynamics, or other physical methods.

Expected number of attendees: 30 maximum