Clathrate hydrates are crystalline inclusion compounds formed from the hydrogen bonding of water molecules (host) enclosing relative small molecules (guest). These structures have unique properties that originate from molecular interactions of the host and guest molecules. Much fundamental knowledge has been gained on clathrate hydrates, especially from the combination of microscopic tools aimed at probing the molecular interactions, both equilibrium and transient, using spectroscopy, diffraction, ab initio calculations, molecular simulations, and theory. This workshop aims to gather a mix of experimental, theoretical, and simulation researchers to state and discuss the latest findings and challenges on clathrate hydrates at the microscopic level. Particular emphasis are given in the synergism to be gained by stimulating discussion among experimentalists, theoreticians, and simulators in the topics of interest include, but not limited to, nucleation and growth, guest-host interactions, guest and host dynamics, structure-properties relations, unusual guests/structure.