The goal of the proposed workshop is to bring together worldwide experts in the field of molecular recognition and protein-ligand binding. The invited speakers will be selected based on their outstanding contributions to our understanding of molecular recognition and ligand association, focusing on two major research criteria: (a) work that provides new physical insight into the molecular recognition process and the driving forces determining thermodynamic signatures of binding and (b) recent methodological advances in applications to predicting and measuring protein-ligand binding observables. In particular, we will stimulate the presentation and discussion of the challenges posed by compensating enthalpic and entropic terms, competing solute and solvent contributions, and the relevance of complex configurational ensembles comprising multiple protein, ligand, and solvent intermediate states. As more complete physics is taken into account, computational approaches increase their ability to complement experimental measurements, by providing a microscopic, dynamic view of ensemble-averaged experimental observables. Physics-based approaches are increasingly expanding their power in drug discovery and design. Therefore, we propose to involve both experimental and computational scientists from industry and academia in a workshop spanning between theory and real-life applications.
If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people. If you have registered for a meeting you were no invited to, you may be subject to a $100 fee.
Registration fee includes 4 lunches.
Telluride Intermediate School
725 W Colorado Avenue Telluride CO 81435
|de Groot, Bert||MPI for Biophysical Chemistry|
|Gilson, Michael||University of California, San Diego|
|Hanson, Sonya||Memorial Sloan Kettering Cancer Center|
|Jorgensen, William||Yale University|
|Klebe, Gerhard||Inst. of Pharmaceut. Chemistry, Univ. of Marburg|
|Lin, Zhixiong||ETH Zurich|
|Lindert, Steffen||University of California, San Diego|
|Luo, Yun||Western University of Health Sciences|
|Minh, David||Illinois Institute of Technology|
|Mobley, David||University of California, Irvine|
|Oostenbrink, Chris||University of Natural Resources and Life Sciences|
|Plattner, Nuria||Free University Berlin|
|Setny, Piotr||University of Warsaw|
|Shirts, Michael||University of Virginia|
|Wand, Josh||University of Pennsylvania|
|Wang, Qiantao||The University of Texas at Austin|
|Zhou, Huan-Xiang||Florida State University|