Workshop Details
Cystic Fibrosis: Ecology, Evolution, and Eradication
08/03/2015 - 08/07/2015
Meeting Description:

The development and application of culture-independent approaches (i.e. high throughput sequencing of bacterial and viral community DNA) has generated a profound shift in our understanding of chronic respiratory infections in cystic fibrosis (CF) patients. We now recognize the importance of polymicrobial interactions, environmental conditions and evolutionary adaptations in the progression of CF disease. Yet, a lack of ecological perspective has limited the translation of bench research into effective therapeutic strategies. For example, how do you describe the response of a bacterial community to an environmental condition, without direct measurements of these conditions in vivo? Recently, applications of integrated ‘omics’ approaches – genomics, transcriptomics, proteomics, and metabolomic profiling – have shed light on the ecological dynamics of CF bacterial communities, though many outstanding questions remain. This will be the 4th bi-annual meeting of the TSRC CF workshop, which began in 2009 with the goal of building theoretical models of CF lung physiology to identify ecological and evolutionary instabilities. We will explore ecological and evolutionary approaches to modeling the CF lung environment and the microbiota that resides there, with the ultimate goal of devising more effective clinical therapy. In addition to a review of the last few TSRC CF meetings, talks from both basic scientists and clinicians will emphasize new tools and hypotheses about the CF bacterial ecosystem and its relation to disease progression. But as with all good Telluride workshops, the aim is to do research on-site. One-hour talks have been known to last an entire afternoon due to intensive probing from the audience. Come prepared to give chalk talks and/or show slides and plots about your work… anything that you feel is important!



Possible Products

A) Models of CF lung that help us identify evolutionary and ecological instabilities

B) Identify missing datasets that are critical for managing CF as an ecosystem

C) Exchange information amongst biologists, clinicians, and mathematicians

Tentative Talks / Discussion Sessions:
Paul Rainey (Massey University & Max Planck Institute for Evolutionary Biology)
Forest Rohwer (SDSU)
Peter Salamon (SDSU)
Doug Conrad (UCSD)
Robert Quinn (SDSU)
Yan Wei Lim (SDSU)
Katrine Whiteson (UC Irvine)
Ryan Hunter (Minnesota)
Megan Bergkessel (Caltech)
Rachel Whittaker (Illinois)
Kirk Harris (Colorado)
Edith Zemanick (Colorado)
Hara Levy (Medical College Wisconsin)
Matt Wargo (Vermont)
Bryan Williams (Minnesota)
Brandie Wagner (Colorado)

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people.

Supporting Files:

Meeting Venue:

Telluride Elementary School
447 West Columbia Ave Telluride C0 81435

Cystic Fibrosis: Ecology, Evolution, and Eradication Registered Meeting Participants:
Participant Organization
Bailey, Barbara San Diego State University
Bean, Heather Arizona State University
Binder, Kelsey University of Minnesota
Carmody, Lisa University of Michigan
Carr, Karen San Juan Bautista School of Medicine
Caverly, Lindsay University of Michigan
Caverly, Lindsay [2nd Reservation] University of Michigan
Conrad, Douglas UC San Diego
England, Whitney Whitney
Felts, Ben San Diego State University
Flynn, Jeffrey University of Minnesota
garg, neha University of California, San Diego
Harris, Kirk University of Colorado
Hunter, Ryan University of Minnesota
Klapper, Isaac Temple University
Lim, Yan Wei San Diego State University
Lucas, Sarah University of Minnesota
Orazi, Giulia Dartmouth
Quinn, Robert UCSD
Salamon, Peter San Diego State University
Wagner, Brandie University of Colorado
Wargo, Matthew University of Vermont
Whiteson, Katrine UC Irvine
Widder, Stefanie University of Vienna

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