While an overwhelming majority of biophysical studies on proteins are performed on dilute solutions, there is now a rapidly growing appreciation of the potential effects of intermolecular excluded volume ("crowding") within the highly volume-occupied cellular interior. A semiquantitative picture of crowding effects in vitro, based on simplified models, has been developed. The next steps toward an understanding of crowding effects within cellular environments are challenging but important for proper modeling of protein functions in vivo. This workshop is organized to address these next steps. Among the topics will be the latest results on the microstructures of the various components of the cytoplasm and on the compositions of the various organelles; the in silico modeling and in vitro mimicking of these complex media, and theories of inhomogeneous fluids that have potential applications to cellular environments. The workshop will serve as a catalyst for new breakthroughs in the study of macromolecular crowding.
If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people
Telluride Elementary School
477 W Columbia Ave
Telluride CO 81435
Participant | Organization | ||||
Clark, Patricia | University of Notre Dame | ||||
Ebbinghaus, Simon | Ruhr University | ||||
Feig, Michael | Michigan State University | ||||
Goldenberg, David | University of Utah | ||||
Howell, Elizabeth | University of TN, Knoxville | ||||
Johnson, Margaret | Johns Hopkins University | ||||
Kim, Youngchan | Naval Reserach Laboratory | ||||
Klumpp, Stefan | Max Planck Institute of Colloids and Interfaces | ||||
Longeville, Stéphane | CEA | ||||
Minton, Allen | NIH | ||||
Pielak, Gary | UNC | ||||
Sapir, Liel | The Hebrew University of Jerusalem | ||||
Schwartz, Russell | Carnegie Mellon University | ||||
Soranno, Andrea | University of Zürich | ||||
Winter, Roland | TU Dortmund University | ||||