Intrinsically disordered proteins (IDPs) have recently attracted widespread attention as they play an important role in cellular signaling pathways and their dysfunction is implicated in a number of cardiovascular and neurological disorders as well as diabetes and cancer. While there has been considerable progress in characterizing IDPs, there are significant challenges including characterizing high-resolution structural details of IDP conformational ensembles, understanding the molecular mechanisms of IDP functions and designing effective therapeutic strategies for dealing with IDP dysfunction. The purpose of this workshop will be to promote cross-disciplinary interactions between experimental, computational and theoretical disciplines to address these aforementioned challenges.