The increase in computer power in tandem with algorithmic and force-field improvements are opening opportunities for modeling large biomolecular systems as never before. Yet many challenges in modeling and simulations of such complex systems in realistic environments require innovations to make the necessary experimental connections and develop new theories and mechanistic details of the associated processes. Our Telluride workshop aims to bring broad-minded scientists interested in these challenges to discuss state-of-the-art approaches and issues with the goal of advancing structural biophysics and allied fields. By discussing various approaches and ways to integrate knowledge on multiple scales, we hope to build a community to advance this important field.