Workshop Details
Challenges in Dissecting and Understanding Nucleic Acid Electrostatics
06/26/2017 - 06/30/2017
Meeting Description:

This workshop aims to address major challenges in nucleic acid electrostatics and their folding and functional processes. DNA and RNA - biological macromolecules with central roles in information storage, gene expression and function - are polyelectrolytes. Thus, an understanding of their structural and functional properties requires a conceptual and quantitative accounting of their electrostatic properties.

However, the polyanionic character of nucleic acids results in complex electrostatic interactions with counter ions, including inner and outer sphere metal ions and formation of an ion cloud surrounding DNA and RNA. These complexities are currently poorly understood and are difficult to model. Further, their understanding will require advances in both theory and experiment and, critically, an interplay between them.

This meeting will bring together experimentalists and theorists to explore avenues for working collaboratively in a more focused manner - to share perspectives about the state-of-the-art RNA electrostatics (theory and experiment) and to identify experimental approaches that would be most helpful in testing and addressing key bottlenecks in theory and modeling. A key goal will be to work toward the development of a framework that will allow blind computational predictions to be independently tested via experiment to meet a critical need of this community.


The registration fee includes five breakfasts, one lunch, a Wednesday-night BBQ picnic, and all the coffee and snacks you can eat.

If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people. If you have registered for a meeting you were not invited to, you may be subject to a $100 fee.

Meeting Venue:

Telluride Intermediate School
725 W Colorado Ave Telluride CO 81435

Challenges in Dissecting and Understanding Nucleic Acid Electrostatics Registered Meeting Participants:
Participant Organization
Al-Hashimi, Hashim Duke University
Bergonzo, Christina NIST
Case, David Rutgers University
Chen, Shi-Jie University of Missouri-Columbia
Feig, Michael Michigan State University
Galindo, Rodrigo University of Utah
Gebala, Magdalena Stanford University
Havenith, Martina Ruhr University Bochum
Lemkul, Justin University of Maryland, Baltimore
Lilley, David University of Dundee
Merriman, Dawn Duke University
PAN, FENG NC State University
Pettitt, Monte University of Texas Medical Branch
Pollack, Lois Cornell University
Ranganathan, Srivathsan University at Albany
Saleh, Omar UC Santa Barbara
Thomas, Dennis Pacific Northwest National Laboratory
Yoo, Jejoong UIUC
Zettl, Thomas Ludwig Maximilian University of Munich

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