Purpose: TAZ (transcriptional co-activator with PDZ-binding motif) was originally identified as a transducer of the Hippo signaling pathway that controls organ size and is now recognized as an important contributor to many types of cancer. TAZ responds to variety of cell signals including G-protein coupled receptors, extracellular mechanical stress, classical kinase cascades and metabolic context. TAZ interacts with TEAD transcription factors and DNA gene expression enhancers to initiate a complex transcriptional program that promotes cell proliferation, migration, and metastasis. TAZ is also potentially involved in a variety of other pathologic states, especially involving fibrosis, such as pulmonary hypertension and emphysema. Eighty years ago Otto Warburg identified a preference among cancer cells to use aerobic glycolysis and this phenomenon is once again a topic of growing interest. Glycolytic flux has recently been identified as important to TAZ activity as well as the pathologic angiogenesis and vessel growth commonly seen in cancers.
The proposed workshop will bring together scientists interested in the diverse responses and cellular effects of YAP/TAZ with the goals of 1) integrating work currently done in separate scientific silos; 2) identifying novel paths to regulating expression and effects of TAZ and 3) identifying potential biomarkers of YAP/TAZ activity. We hope that collaborations stimulated by this workshop will lead to new potential treatments for YAP/TAZ-driven cancers.
While the registration fee is currently set at $0, there is actually a charge for registration that will be processed at a later date, depending on the scientists that apply for registration sponsorship support from the CRAVAT Foundation, the workshop sponsor. The actual early bird registration fee is $290 if registration occurs by January 15, 2017, and $390 after the early bird registration date.
The registration fee includes five breakfasts, a Wednesday-night BBQ picnic, and all the coffee and snacks you can eat.
If you're interested in applying for registration sponsorship from the CRAVAT Foundation, please send a short workshop goals statement (100-200 words) to the lead organizer, Guy Weinberg.
If you are interested in attending a meeting, but have not received an invitation, please contact the workshop organizer about availability before registering. Most TSRC meetings are very small, typically only about 25 people. If you have registered for a meeting you were not invited to, you may be subject to a $100 fee.
Telluride Intermediate School
725 West Colorado Ave Telluride, CO 81435
|Chan, Stephen||University of Pittsburgh|
|Costi, Maria Paola||University of Modena and Reggio Emilia|
|Cunningham, Christian||Genentech, Inc.|
|Dey, Anwesha||Genentech Inc.|
|Guan, Kun-Liang||University of California, San Diego|
|Lamar, John Michael||Albany Medical College|
|Pan, Duojia||UT Southwestern Medical Center|
|Pobbati, Ajay||Institute of Molecular and Cell Biology|
|Rubin, Brian||Cleveland Clinic|
|Salamon, Peter||San Diego State University|
|SUDOL, Marius||National University of Singapore|
|Tanas, Munir||University of Iowa|
|Varelas, Bob||Boston University|
|Weinberg, Guy||University of Illinois|