Single-molecule/single-cell experiments are becoming increasingly popular as the preferred method for probing complex molecular phenomena, in particular those inherent in living systems and heterogeneous materials. Uncovering the underlying dynamics from such experimental signals presents a major challenge and is the subject of much recent experimental and theoretical effort. The purpose of this workshop is to bring together contributors in the fields of single-molecule spectroscopy, single-molecule/cell force spectroscopy, single-cell imaging, and single-molecule theory to discuss recent advances in these fields, with a particular focus on issues at the interface between experiment and simulation/theory. This year, our workshop will highlight the following topics:

1) Fluctuation theory, detailed balance, non-equilibrium thermodynamics

2) Chemical kinetics, enzymatic networks, gene networks, cell cycles

3) Data analysis, statistics, information entropy

4) DNA and other biopolymers, molecular motors, cytoskeletons, cell mechanics

5) Single-molecule photophysics, photon statistics