Charged with the mission of expanding chemical space and finding new small molecules that can function as chemotherapeutics and/or chemical probes, chemists are searching for methods to accelerate and broaden the reaction discovery process. This process has traditionally been guided by the needs of natural product synthesis and has focused on one chemical transformation at a time. The challenges associated with accelerating reaction discovery is best realized via a multidisciplinary approach combining theory and experiment. The purpose of this meeting is to bring together a group of chemists with diverse interests (computational, analytical, mechanistic and synthetic) with a common goal of accelerating reaction discovery. Attendance will be limited to approximately 15 people, all of whom will present their research. The presentations are intended to be highly interactive and not limited to the traditional 45-60 minute format. This will enable a depth of discussion not available in any other meeting venue.